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Insomnia linked to 26% higher stroke risk, study finds

Insomnia

LONDON: People suffering from insomnia may face a significantly higher risk of stroke, according to a new study published in the journal Sleep Medicine Reviews.

Sleep is essential for both physical and mental health, but millions of people worldwide experience insomnia for a variety of reasons. While short-term sleep problems may resolve within days, persistent insomnia has been linked to a range of health problems.

Researchers conducted a comprehensive analysis of previous studies examining the relationship between insomnia and stroke. Nine studies investigated the association, involving more than 1.3 million people in total.

The analysis found that people with insomnia had a 26% higher risk of stroke and a 28% higher likelihood of hospitalization from any cause.

The researchers said the findings highlight the potential health consequences of persistent insomnia and its association with neurological problems.

However, they cautioned that the analysis identified an association rather than proving that insomnia directly causes stroke. Further research is needed to determine the mechanisms behind the relationship.

Previous research published in BMJ Open in March 2024 also found that regular exercise was associated with a lower risk of insomnia symptoms.

That study analyzed data from 4,339 people across nine European countries. Participants were assessed for their physical activity at the beginning of the study and again about a decade later, while researchers also collected information about symptoms of insomnia.

The findings showed that people who exercised at least twice a week were 22% less likely to experience insomnia symptoms.

HIV-affected children at Valika Hospital rise to 169

HIV-affected

KARACHI: The number of children linked to the HIV outbreak at Kulsum Bai Valika Hospital has risen to 169, with 142 registered with medical boards formed to oversee their registration and support, hospital sources said Friday.

Five medical boards have so far been constituted to register affected children and address matters related to financial assistance and other support.

According to hospital sources, bank accounts have been opened for 109 affected children or families as part of efforts to provide financial assistance. Under an endowment fund established for affected families, financial assistance has begun for 76 families, with payments for two months already transferred.

However, 34 affected families are still awaiting financial assistance due to incomplete documentation and issues related to Benazir cards, sources said.

The HIV cases at the hospital have been under investigation for several months. The number of affected children was initially reported at 78 at the government level, but subsequent screening and testing led to an increase in the reported cases.

Nine deaths of HIV-affected children have so far been confirmed, although the hospital’s own records list only two deaths, resulting in a discrepancy in the reported fatalities. Families of the deceased have not yet received financial assistance from the endowment fund.

The issue of providing assistance to families of deceased children is expected to be discussed at an upcoming meeting, where officials may decide the amount and mechanism of financial support.

Several inquiries have been launched into the cases, while administrative action has also been taken against hospital staff. Show-cause notices have been issued to several employees, while doctors, dispensers and nursing staff have faced suspensions and other disciplinary measures.

Authorities have said affected children are being provided treatment, medicines, tests and other necessary facilities. However, the latest figures indicate that registration, financial assistance, discrepancies in death records and rehabilitation of affected families remain unresolved issues.

FDA approves Lilly’s once-weekly insulin injection for type 2 diabetes

FDA approves

WASHINGTON: The U.S. Food and Drug Administration has approved Eli Lilly’s once-weekly basal insulin for adults with type 2 diabetes, giving patients an alternative to daily long-acting insulin injections.

Lilly said its Onswik, chemically known as insulin efsitora alfa-globe, is indicated alongside diet and exercise to help control high blood sugar.

The company said the once-weekly treatment could reduce the injection burden by more than 300 injections a year compared with once-daily basal insulin.

Onswik is expected to become available in the United States in the coming months as a prefilled KwikPen in concentrations of 500 units per milliliter and 1,000 units per milliliter.

The FDA approval was based on four clinical trials involving more than 3,400 adults with type 2 diabetes. Onswik met the primary objective in each study, producing reductions in A1C, a measure of average blood sugar levels, that were not inferior to those achieved with daily insulin glargine.

Insulin glargine is used to control blood sugar in people with type 1 and type 2 diabetes and is sold under brands including Sanofi’s Lantus and Lilly’s Basaglar.

Lilly said Onswik has previously received regulatory clearance in Europe, Japan and Mexico.

Peshawar Umrah travelers face mandatory vaccination from Oct. 15

Peshawar Umrah

KARACHI/Peshawar: The deadline for Umrah pilgrims traveling from Karachi without vaccination has been extended by 15 days, while vaccination will become mandatory for Umrah pilgrims and Saudi visit visa travelers departing from Peshawar, officials said Wednesday.

Dr. Syed Murtaza Shah Bukhari, focal person for the Federal Airport Health Department and Border Health Services, said Karachi-based Umrah pilgrims could travel without vaccination until Oct. 10.

He said the extension was granted to facilitate pilgrims. Five National Database and Registration Authority (NADRA) facilitation centers have been established at the Karachi airport dispensary, while vaccination will begin next week at the Jacob Lines dispensary.

For travelers departing from Peshawar, vaccination will be mandatory from Oct. 15 for Umrah pilgrims and Saudi visit visa travelers. Umrah pilgrims from Peshawar can travel without vaccination until Oct. 14.

A vaccination center has been established at the Civil Surgeon’s Office in Peshawar, with 20 counters for men and women. Two NADRA facilitation centers are also being established there.

Bukhari advised travelers to get vaccinated at least 10 days before their departure.

Xanthelasma around eyes may signal higher heart disease risk

Xanthelasma

A yellowish, fatty deposit that appears around the inner corners of the eyes could be a visible sign associated with an increased risk of cardiovascular disease, according to research published in the journal Atherosclerosis.

The condition, known as xanthelasma, causes yellowish fatty deposits to develop near the skin around the eyes. While the deposits themselves are generally not considered dangerous, they can be associated with elevated cholesterol levels, which are a major risk factor for heart disease.

Researchers analyzed data from nearly 18,000 people with xanthelasma and compared them with people who did not have the condition.

The study found that people with xanthelasma had a two to three times higher risk of cardiovascular problems, including heart attacks and strokes, compared with those without the condition.

The increased risk remained evident even after 10 years, according to the researchers.

Cardiovascular disease includes conditions affecting the heart and blood vessels, including heart attacks and irregular heart rhythms. High blood pressure, high cholesterol and smoking are among the established risk factors for cardiovascular disease.

The researchers said the fatty deposits associated with xanthelasma may indicate elevated cholesterol levels in the body. However, having xanthelasma does not by itself mean that a person has heart disease.

The researchers also acknowledged limitations in the study and said further research is needed to better understand the relationship between xanthelasma and cardiovascular disease.

Early identification of cardiovascular risk factors, including high cholesterol and high blood pressure, can help people and their doctors take steps to reduce the risk of serious complications.

Poliovirus found in environmental samples from Karachi, Hyderabad

Poliovirus found

KARACHI: Poliovirus has been detected in environmental samples collected from four Karachi districts and Hyderabad in August, according to a report by Sindh’s Emergency Operations Centre.

The report said poliovirus was found in one environmental sample each from Karachi’s West and Korangi districts, while one sample each from the Central and South districts also tested positive.

Two environmental samples collected in Hyderabad also tested positive for poliovirus.

No poliovirus was detected in environmental samples from Karachi’s East, Keamari and Malir districts, the report said.

Samples collected from Ghotki, Sukkur, Jacobabad, Qambar, Larkana, Kashmore, Dadu, Badin, Jamshoro, Sujawal, Mirpurkhas and Sanghar also tested negative for the virus.

The Emergency Operations Centre said authorities would increase their focus on polio vaccination and other preventive measures in districts where positive environmental samples were detected.

Juvenile card requirement dropped for MDCAT candidates in Sindh

Juvenile card

KARACHI: The mandatory juvenile card requirement for candidates appearing in the Medical and Dental College Admission Test (MDCAT) 2026 in Sindh has been waived, allowing students without the document to take the exam.

According to a press release, the relaxation was approved by the MDCAT committee on the instructions of the Sindh Health Department.

Candidates who do not have a juvenile card have been directed to bring their original, photograph-bearing marks sheet for identification at the examination center.

The original marks sheet for either matriculation or intermediate will be accepted, and candidates’ identities will be verified against the document at the test center.

The press release said the requirement was relaxed to facilitate candidates who did not have juvenile cards.

The MDCAT 2026 examination in Sindh will be conducted by Sukkur IBA Testing Services.

Sindh to hold MDCAT 2026 examination on Sept 20

Sindh

KARACHI: The Medical and Dental College Admission Test (MDCAT) for admission to medical and dental colleges in Sindh will be held Sunday, September 20, with examination centers established in seven cities across the province.

The test will be conducted in Karachi, Hyderabad, Jamshoro, Mirpurkhas, Larkana, Shaheed Benazirabad and Sukkur.

In Hyderabad, the Public School Unit No. 3 in Latifabad has been designated as the examination center. In Jamshoro, the test will be held at Liaquat University of Medical and Health Sciences.

Mir Sher Muhammad Talpur Public School has been designated as the center in Mirpurkhas, while the Police Training School Ground will host the examination in Larkana.

In Shaheed Benazirabad, the examination center will be at Quaid-e-Awam University of Engineering, Science and Technology. In Sukkur, candidates will take the test at IBA Public School on Old Airport Road.

The SIBA Testing Services said maps of the examination centers had also been released to help candidates. Separate entrance routes have been marked on the maps for the NED University and Dow University centers in Karachi.

SIBA Testing Services advised candidates to check their reporting time, examination center and designated entrance in advance.

The MDCAT examination will last three hours. Question papers will be collected from candidates after the examination, according to SIBA Testing Services.

Faster biological aging may explain rising cancer rates among young adults

Faster biological

WASHINGTON: Faster biological aging may be one of the key factors behind the rising incidence of cancer among younger adults, according to a study by researchers at Washington University School of Medicine.

Cancer has traditionally been associated with older age, with the risk generally increasing as people grow older. However, cancer rates among people under 50 have increased in recent years, while the reasons for the trend remain unclear.

The researchers examined whether changes in biological age could help explain the increase.

Unlike chronological age, which is determined by a person’s date of birth, biological age reflects the condition and functioning of the body. Genetics, lifestyle and other factors can influence biological aging, which in turn can affect the risk of various diseases.

The study found that younger generations are experiencing faster increases in biological age compared with people from earlier generations.

Researchers said accelerated biological aging can lead to changes in cells, organs, metabolism and other body systems. A larger gap between biological and chronological age was associated with a higher risk of cancer among younger adults.

The effects were not uniform across the body, with accelerated biological aging appearing to be more pronounced in organs commonly associated with cancer.

The research team also noted that several factors, including body weight, declining metabolic health, alcohol consumption, prolonged sedentary behavior and unhealthy diets, can contribute to the risk of various cancers.

For the study, researchers analyzed data from more than 154,000 people and compared the findings with another group of about 10,000 participants.

The analysis found that biological age increased more rapidly among younger people in the study. The difference was particularly pronounced among people born between 1990 and 1999, whose rate of biological aging was 92% higher than that of people born between 1965 and 1969.

Further analysis indicated that accelerated biological aging was associated with an up to 8% increase in the risk of developing cancer at a younger age, with particularly notable associations involving lung and digestive-system cancers.

The findings were published in the journal Nature Medicine.

Lucy Letby inquiry reveals missed chances to protect seven babies

Lucy Letby

LONDON: An independent inquiry into the case of convicted British nurse Lucy Letby has found serious failures in the management and safeguarding systems at the Countess of Chester Hospital, saying seven babies could have been protected from harm if concerns had been acted upon sooner.

The Thirlwall Inquiry, led by Lady Justice Catherine Thirlwall, examined events surrounding the deaths and collapses of babies in the hospital’s neonatal unit.

According to the final report, at least three babies could have survived if timely action had been taken, while four others could have been protected from harm.

The inquiry found that the hospital’s safeguarding system had effectively failed, with weaknesses in management structures, poor communication between medical staff and leadership, and a lack of understanding of basic safeguarding procedures contributing to delays in taking action against Letby.

The report said five babies, including a set of twins, could have been protected if Letby had been removed from the neonatal unit earlier. Three additional cases could also have been addressed through timely medical investigation and recognition of evidence involving insulin.

One of the affected children, now 11, suffered brain damage and requires round-the-clock care, according to the report.

The inquiry recommended that hospitals should not wait for conclusive evidence before taking protective action when there is a reasonable suspicion that a healthcare worker may be deliberately harming patients.

Doctors’ concerns were ignored

The report said some senior doctors had raised concerns about unusual infant deaths and a rise in medical complications while Letby was working in the neonatal unit.

However, senior nursing and administrative officials failed to respond promptly to those concerns, the inquiry found.

It also criticized delays in contacting police. After Letby was eventually removed from the neonatal unit, some doctors who had raised concerns reportedly faced investigations following a complaint made by the nurse.

Parents kept in the dark

The inquiry found that parents were not fully informed for years about what had happened to their children or about concerns that they may have been deliberately harmed.

It described the failure to provide families with relevant information as deeply regrettable and said affected parents should not have been left on the sidelines of discussions about Letby’s criminal responsibility.

Cameras recommended for neonatal units

The inquiry made 14 recommendations aimed at preventing similar incidents in the future.

Among the key proposals is the installation of monitoring systems at neonatal beds and incubators that would allow parents to remotely view their babies.

It also recommended CCTV cameras around refrigerators and cabinets used to store insulin, along with digital controls limiting access to authorized staff and maintaining records of access to the medication.

British Health Secretary Wes Streeting said the government had ordered immediate work on plans to introduce cameras in neonatal units.

Management reforms proposed

The inquiry also called for changes to hospital management and greater personal accountability among NHS managers.

It recommended a new code of conduct for senior managers and measures to prevent managers from simply being transferred to another hospital following serious failures or misconduct.

Training on patient safety and how to respond to suspected deliberate harm should also be provided to all staff, including hospital boards and non-executive directors.

Lucy Letby remains in prison

Letby, 36, was convicted in 2023 of murdering seven babies and attempting to murder seven others. She was sentenced to 15 whole-life orders.

She continues to deny the allegations and convictions and is pursuing legal efforts to overturn her sentence.

The Thirlwall Inquiry did not determine whether Letby’s convictions were correct. It proceeded on the basis that she had already been convicted by a court.

Her case is also being reviewed by the Criminal Cases Review Commission, an independent body that examines potential miscarriages of justice. The commission has said it will consider the Thirlwall Inquiry’s findings as part of its review.

Hospital apologizes

The Countess of Chester Hospital NHS Foundation Trust apologized following publication of the inquiry report, expressing regret over the events of 2015 and 2016.

The trust said it is now a different organization with new leadership, improved management systems and stronger safeguarding procedures.

Letby worked in the hospital’s neonatal unit from June 2015 to June 2016. Prosecutors said she harmed babies by injecting them with dangerous amounts of insulin, introducing air into their bodies and force-feeding them milk.

The case has raised major questions in Britain about patient safety, the supervision of medical staff and accountability within hospital management.