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Men face higher cancer rates than women, study finds

Men face

LONDON: Men have higher rates of cancer than women worldwide, although the overall potential for developing the disease is considered similar between the sexes, according to a new study published in JAMA Oncology.

Researchers analyzed health data from more than 134,000 people in Shanghai, China, and more than 455,000 people in the United Kingdom. They examined the incidence of 34 types of cancer and compared the findings with 11 potential risk factors.

Previous studies have pointed to biological differences, including genes, hormones and immune-system responses, as possible explanations for the disparity. Lifestyle factors such as smoking, poor diet, obesity and metabolic diseases have also been linked to increased cancer risk.

For the new study, researchers examined factors including smoking, alcohol consumption, diet and certain medical conditions. Participants were followed for more than a decade to determine how many developed cancer.

The findings suggested that lifestyle-related factors accounted for about 85% of the difference in cancer rates between men and women, while biological factors or unexplained causes accounted for the remaining 15%.

In China, smoking was the largest contributor to the difference, accounting for about 52% of the disparity in cancer cases between men and women. Alcohol consumption accounted for another 15.1%.

Chronic liver disease and low fruit consumption were also associated with higher cancer risk among men.

The pattern was different in the United Kingdom, where smoking and alcohol consumption rates were more similar between men and women. Metabolic factors such as obesity accounted for about 8% of the difference, followed by smoking at 6.26% and type 2 diabetes at 3.51%.

The researchers said the findings indicate that differences in cancer rates between men and women are not solely attributable to biological factors and may also be influenced by cultural practices and population health.

They added that future research should examine other potential contributors, including environmental factors.